N,N-Dimethyltryptamine molecular structure. This diagram does not show a finished medicine or identify a pill.
PubChem / National Library of Medicine · Structure images reusable under PubChem citation guidelinesAbout N,N-Dimethyltryptamine
N,N-Dimethyltryptamine (DMT) is a tryptamine psychedelic. It is chemically distinct from 5-MeO-DMT and 4-AcO-DMT, which have their own evidence and risks.
Also searched as: N,N-DMT · DMT
Buy DMT: pricing & legal access
DMT online: availability & product information
DMT is federally listed in Schedule I in the United States. An online listing does not establish lawful access. DrugRX does not list sellers or street prices; research access and any recognized exemptions require their own authorization.
Pricing status: No live price feed or verified quote. DrugRX does not sell or dispense products.
Sources: DEA — Controlled substances alphabetical list (October 2026)
DMT information
What is DMT?
DMT alters perception and awareness. It occurs in certain plants and is associated with ayahuasca preparations, whose additional ingredients change the pharmacology. Findings about a particular preparation cannot automatically be applied to isolated DMT.
Sources: DEA — N,N-Dimethyltryptamine
Effects and health risks
Reported effects include intense perceptual changes, agitation and increased heart rate. Impaired awareness can contribute to injury. Severe distress or an altered level of consciousness requires medical assessment.
Sources: DEA — N,N-Dimethyltryptamine
Dosage and research context
This reference does not establish a self-use dose. Investigational products and study protocols are not equivalent to powders or preparations of uncertain composition.
Interactions
Ayahuasca preparations may include monoamine oxidase inhibitors. These create a different interaction profile from DMT alone; disclose psychiatric medicines and supplements to a clinician.
Sources: DEA — N,N-Dimethyltryptamine
Chemical identity and related tryptamines
N,N-DMT contains a tryptamine core with two methyl groups on its terminal nitrogen. The prefixes in 5-MeO-DMT and 4-AcO-DMT describe additional chemical changes, not brand variants of N,N-DMT.
Sources: DEA — N,N-Dimethyltryptamine
DMT and ayahuasca are different preparations
Ayahuasca is a preparation containing multiple substances. Harmala alkaloids can inhibit enzymes that otherwise metabolize DMT. The resulting exposure and interaction context differs from isolated DMT.
| Name | What it describes |
|---|---|
| N,N-DMT | One chemical compound |
| Ayahuasca | A multi-ingredient preparation |
| 5-MeO-DMT | A different tryptamine |
Sources: DEA — N,N-Dimethyltryptamine
What a DMT study can establish
A study using a characterized DMT product can examine that material under its specified conditions. It cannot establish the composition of a preparation sold under an informal name, or transfer findings unchanged to a different tryptamine.
DMT versus psilocybin
DMT and psilocybin are different tryptamines. Psilocybin is associated with conversion to psilocin, while ayahuasca introduces additional pharmacologically active ingredients. Similar descriptions of altered perception do not establish identical metabolism or clinical use.
Sources: DEA — N,N-Dimethyltryptamine · NIH NCCIH — Psilocybin for mental health and addiction
Sources and editorial notes
Prepared by DrugRX using the references linked below. Sources were consulted on 2026-10-31. This page has not been independently reviewed by a clinician. Research findings, medication approval and legal permission are separate questions.
- DEA — N,N-Dimethyltryptamine
- FDA — Psychedelic drugs: clinical investigations
- NIH NCCIH — Psilocybin for mental health and addiction
- DEA — Controlled substances alphabetical list (October 2026)
Legal information is a dated U.S. reference. Product rules and local laws may change. Where the evidence does not establish a dose, interaction profile or price, the page states that limitation.