Zoloft (sertraline) 100 mg tablet, front face.
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About Sertraline
Sertraline, sold as Zoloft and generics, is a selective serotonin reuptake inhibitor antidepressant.
Also searched as: Zoloft
Available strengths
Strength is the amount in a tablet, capsule, liquid or patch. Different formulations are listed separately.
| Product & formulation | Strengths |
|---|---|
| Zoloft / sertraline Oral tablet | 25 mg · 50 mg · 100 mgProduct label · Checked 2026-10-31 |
Dosages in the product label
Zoloft / sertraline — Major depressive disorder
Population: Adults
Initial: 50 mg once daily. Maximum: 200 mg/day.
Other indications may start at 25 mg/day. Mild hepatic impairment requires lower starting and maximum doses.
Prescribing information · Checked 2026-10-31
Zoloft / sertraline — Panic disorder, PTSD or social anxiety disorder
Population: Adults
Initial: 25 mg once daily. Maximum: 200 mg/day.
Subsequent changes are generally no more frequent than weekly; limits differ for PMDD.
Prescribing information · Checked 2026-10-31
Buy Sertraline: pricing & legal access
Sertraline online: availability & product information
Saved U.S. price estimates from Drugs.com for the exact products and quantities below. These are dated estimates, not live pharmacy quotes or insurance copays. Discounts and local availability vary.
| Product / strength | Quantity | Price (USD) |
|---|---|---|
| Sertraline hydrochloride 100 mg Oral tablet | 30 tablets | $5.04–$10.19 Drugs.com published cash estimate Drugs.com price guide Checked 2026-10-31 |
Prices refer to medication only; consultation, administration and monitoring costs may be additional. Prescription products require a valid prescription and a licensed pharmacy. Check the exact formulation before comparing offers.
Sertraline information
Uses and formulations
Used for depression, OCD, panic disorder and certain other conditions. Benefits develop over time rather than immediately after one dose.
Sources: MedlinePlus — Sertraline
Side effects and serious risks
Nausea, diarrhea, sleep changes and sexual side effects can occur. New suicidal thoughts, severe agitation or serotonin syndrome need urgent assessment.
Sources: MedlinePlus — Sertraline
Dosage and directions
Take consistently as prescribed. Do not stop suddenly; gradual changes may reduce discontinuation symptoms.
Sources: MedlinePlus — Sertraline
Interactions and precautions
MAO inhibitors and other serotonergic medicines can interact. Bleeding risk and bipolar history also need review.
Sources: MedlinePlus — Sertraline
Pharmacology and mechanism
Sertraline inhibits serotonin reuptake. Clinical improvement develops over time; an immediate feeling after one tablet does not measure the full treatment response.
Formulations and product identification
The active ingredient alone does not describe a finished product. These distinctions matter when reading a label or comparing prescriptions.
| Product or formulation | Important distinction |
|---|---|
| Tablets | Strength and prescribed schedule need confirmation. |
| Oral solution or concentrate | Uses product-specific preparation instructions. |
Monitoring and treatment follow-up
Review symptom changes, sleep, sexual adverse effects and gastrointestinal effects. New mania-like symptoms, suicidal thinking, severe agitation or unusual bleeding require assessment rather than assuming they are expected adjustment effects.
Dependence and stopping treatment
Stopping can cause discontinuation symptoms such as dizziness, sleep changes or sensory disturbances. This is not the same as addiction. Reductions are planned around the individual’s response and duration of treatment.
How it differs from related medicines
Zoloft contains sertraline. It is not the same as bupropion, which has a different pharmacologic profile. Switching or combining antidepressants requires attention to interactions and timing, not simply a choice between brand names.
Sources and editorial notes
Prepared by DrugRX using the references linked below. Sources were consulted on 2026-10-31. This page has not been independently reviewed by a clinician. Research findings, medication approval and legal permission are separate questions.
Legal information is a dated U.S. reference. Product rules and local laws may change. Where the evidence does not establish a dose, interaction profile or price, the page states that limitation.